Birmingham give late fitness tests to the ill Callum Reilly and to Jonathan Spector, who has an ankle injury. Leeds will be without last week's signings, Michael Tonge and Ross Barkley, but Adam Drury returns. A home tie against Tottenham awaits.
Wigan will name another unfamiliar side, and may give a debut to Angelo Henríquez, on loan from Manchester United. Matt Tubbs could return to the starting line-up for Bournemouth, unbeaten in 18 games in all competitions.
Southend's Marc Laird is out after suffering a hamstring injury in Saturday's 3-0 defeat at Exeter, and Britt Assombalonga may join him on the sidelines. Brentford are without Lee Hodson. The winners play Chelsea in round four.
Hull, who needed a 94th-minute equaliser to earn the replay, could play their goalkeeper Eldin Jakupovic despite a facial injury suffered on Saturday. The Orient forward Charlie MacDonald is cup-tied and Kevin Lisbie injured.
Wednesday's David Prutton is suspended and Jérémy Hélan – like the Dons' Izale McLeod – is cup-tied. Gary MacKenzie, who has not started since September, and Jon Otsemobor, once of Wednesday, will be involved for the Dons.
The goalkeeper Thomas Sorensen and Michael Owen are likely to start for Stoke, with Tony Pulis insisting "we want to do well in the Cup". Palace are without Kagisho Dikgacoi, who is at the Africa Cup of Nations, and the injured Owen Garvan.
Sunderland new boys Alfred N'Diaye and Kader Mangane are unavailable for the match. Stuart Holden and Josh Vela could make their comebacks from long-term injury for Bolton, who were 2-0 up with 30 minutes to play in the original game.
Dimitar Berbatov is expected to be rested by Fulham, for whom Steve Sidwell is struggling with a hamstring injury. Blackpool will be without the cup-tied Wes Thomas. A trip to Manchester United or West Ham will be the winners' reward.
Peter Odemwingie has recovered from a calf strain and could play against QPR, who made public their interest in him over the weekend, while Steven Reid returns after a shin injury. QPR report no new concerns.