Arsenal's hopes of contesting next month's Women's Champions League final, to be staged at Chelsea's Stamford Bridge, were dashed on an afternoon that saw England's finest outclassed by Germany's new girls on the European block.
Wolfsburg, in their first season of Champions League competition but now – unlike Arsenal's semi-professionals – playing full-time after a massive cash injection into the women's section of the Bundesliga club, were in command from the early stages.
They had been a shade fortunate to come out of the first leg at Boreham Wood FC's Meadow Park last Sunday with a two-goal lead, but they were more than worthy of a victory on home soil that took them through 4-1 on aggregate.
A 14th-minute goal by the striker Selina Wagner put Wolfsburg firmly in control of the tie, and more goals should have followed for the home team before the Arsenal midfielder Kim Little equalised nine minutes after the interval.
But the decisive strike followed seven minutes later, the home side's captain, Nadine Kessler, scoring to send Wolfsburg through and Arsenal out at the semi-final stage for the third successive season.
The recently appointed Arsenal Ladies manager, Shelley Kerr, for whom this was a first European campaign, said: "I'm disappointed but realistic. Over the two legs Wolfsburg deserved to go through to the final.
"We didn't play well in the first half today and we could have been three goals behind by half-time. But after we equalised we started to play a bit and I thought we were in with a right good chance.
"We showed good character in the second half, but Wolfsburg got all the fine details spot-on and they were better than us."
Arsenal never looked capable of wresting control from the home side after Wagner's looping header struck the underside of the bar and then the far post before crossing the line for the first goal.
Kessler, the striker Conny Pohlers and the left winger Martina Müller then all wasted good opportunities before Wagner shot against the angle of post and bar just after the interval.
Arsenal drew level when Little traded passes with Jordan Nobbs to drive a low 20-yard shot just inside the far post.
But the reigning Women's Super League champions' fate was sealed when Kessler forced the ball over the line after the Arsenal goalkeeper, Emma Byrne, had blocked her penalty, awarded for a handball by Little.
VfL Wolfsburg (4-4-2) A Vetterlein; Wensing, Henning, Goessling (Hartmann 90), Faisst; Blasse, Kessler, Odebrecht, Müller; Pohlers (Magull 80), Wagner (Omilade-Keller 87)
Subs not used Burmeister, L Vetterlein. Jager, Tietge.
Arsenal (4-1-4-1) Byrne; Scott, Grant, Flaherty (Carter 80), Fahey; Houghton (Ludlow 80); Davison, Nobbs, Little, Yankey (Beattie 65); White.
Subs not used Spencer, Tracey, Bailey.
Referee Ms S Spinelli (Italy)